منابع مشابه
Effects of restraint stress on the daily rhythm of hydrolysis of adenine nucleotides in rat serum
BACKGROUND Adenosine 5-triphosphate (ATP) and its breakdown products ADP and adenosine can act as extracellular messengers in a range of biological processes. Extracellular adenine nucleotides are metabolized by a number of enzymes including NTPDases and 5'-nucleotidase, which are considered to be the major regulators of purinergic signaling in the blood. Previous work by our group demonstrated...
متن کاملThe enthalpy of hydrolysis of various 3',5'-and 2',3'-cyclic nucleotides.
The enthalpy of hydrolysis of the 3’-bond of several cyclic 3’,5’-nucleotides and of the 2’-bond of several cyclic 2’,3’nucleotides has been measured calorimetrically. In each case, the enthalpy was indicative of a high energy bond, although values for different compounds varied from -7.7 to 14.1 kcal mole-‘. The enthalpy of hydrolysis of the cyclic 3’,5’-nucleotides, but not that of the cyclic...
متن کاملEffects of extracellular nucleotides and their hydrolysis products on regulatory volume decrease of trout hepatocytes.
In trout hepatocytes, hypotonic swelling is followed by a compensatory shrinkage called regulatory volume decrease (RVD). It has been postulated that extracellular ATP and other nucleotides may interact with type 2 receptors (P(2)) to modulate this response. In addition, specific ectoenzymes hydrolyze ATP sequentially down to adenosine, which may bind to type 1 receptors (P(1)) and also influen...
متن کاملCrystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides
We have determined the crystal structure of an active, hexameric fragment of the gene 4 helicase from bacteriophage T7. The structure reveals how subunit contacts stabilize the hexamer. Deviation from expected six-fold symmetry of the hexamer indicates that the structure is of an intermediate on the catalytic pathway. The structural consequences of the asymmetry suggest a "binding change" mecha...
متن کاملThe Enthalpy of Hydrolysis of Various 3 ’ , 5 ’ - and 25 3 ’ - Cyclic Nucleotides
The enthalpy of hydrolysis of the 3’-bond of several cyclic 3’,5’-nucleotides and of the 2’-bond of several cyclic 2’,3’nucleotides has been measured calorimetrically. In each case, the enthalpy was indicative of a high energy bond, although values for different compounds varied from -7.7 to 14.1 kcal mole-‘. The enthalpy of hydrolysis of the cyclic 3’,5’-nucleotides, but not that of the cyclic...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1920
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)86286-x